Before taking Viagra, tell your doctor if you have: sickle cell anemia (an abnormality of red blood cells), leukemia (blood cancer), multiple myeloma (cancer of the bone marrow), heart disease, liver disease or illness / deformity of the penis, what that it is. In these cases, it may be necessary to take special precautions when taking medications for the treatment of erectile dysfunction; recently been the victim of an attack or myocardial infarction, or if your blood pressure is low; rare eye disease (such as retinitis pigmentosa), gastric ulcer or disorder of blood clotting (eg, hemophilia). Viagra may have adverse effects on these diseases. Do not use Viagra at the same time as another treatment for erectile dysfunction. Inform your doctor about all medications you are taking. Viagra tablets filmed can interfere with other medications, especially those used to treat chest pain. Do not take Viagra with other medicines if your doctor told you that you can. Viagra can seriously enhance the effects of drugs that contain nitrates, or substances which release nitric oxide (eg molsidomine, the nytroglycerine or similar substances). These are drugs often used to alleviate problems caused by angina pectoris (or "heart pain"). You should not take Viagra if you are using these drugs. Similarly, you should not use amyl nitrite, a substance sold illegally contained in so-called "poppers". There are a number of drugs that slow or prevent the degradation of the active ingredient of Viagra in the liver. The effect of Viagra is strengthened but its adverse effects, including the frequency and severity may increase. Among these drugs are among some other antibiotics ("macrolides" such as erythromycin), medicines against fungal infections (eg ketoconazole), certain drugs used in AIDS (protease inhibitors) or drugs against excessive gastric acid secretion or gastric ulcers, which is the active ingredient cimetidine. If you are taking protease inhibitors for the treatment of HIV, your doctor may prescribe Viagra starting with the lowest dose (25 mg). Please tell your doctor if you are taking anticoagulants (medicines to "dilute" the blood) or drugs to lower voltage is too high. If you suffer from any disease, if you have any allergies or if you are taking other medicines (even self-medication), notify your doctor. Taking Viagra may occasionally cause dizziness and blurred vision (lasting several hours), such as blurred vision or abnormal color perception. It is therefore necessary that you know how you react to Viagra before driving or you use a machine. It must also be taken into account for activities where a clear distinction of color is essential.
Viagra official site
As more people consume prescription Viagra pills and other no RX medications, European pharmacy giants expand cost tags on their tablets. However, in last years, the suppress on the pharmaceutical market has been inquired by an unlikely challenger - India.
Drug makers from America pursue in excellent generic tablets. Generic meds are much mattering substitute to branded alternative, providing comparable drugs, but at a lesser rate.
One of the drug manufacturers presently creating a huge invasion on USA market is Cipla. This India-located corporation has progressed in last years, cooperating for the world’s biggest pharmaceutical giants to make positive friendship with Western purchasers. Cipla has met Food and Drug Administration criterions with its pills, assuring the safety and class of the drugs for the North American people.
Though it makes countless medication, Cipla has gained the most attention to its Viagra-like medicaments. These medicaments are generic counterparts to the popular Erectile Dysfunction tablet - Viagra, and have been pursued by consumers of all ages who suffers from ED. The Cipla's generic options have been declared to be as riskless and effective as the brand medicaments.
While the safety and performance of Cipla’s pills are important, those things are not the only ideas why Cipla is such a top manufacturer in the pharmaceutical market. As compared with brand meds such as Viagra, Cipla’s generic substitutes are available at lower price. In fact, majority of Cipla’s cures can be obtained at 1/20th of the price. For example, its Viagra-like pills each cost approximately $1.8 as compared to $20 in America. This great cost decrease not only makes these tablets more widely available to the society, but they also put free market pressure on branded pharmacies to lower their prices in order to be competitive.
Viagra or levitra
More consumesrs obtain rx Viagra and other non prescription medications, USA pharmacy giants enlarge costs tags on their tablets. However, in last several years, this monopoly on the pharma market has been inquired by an unlikely country - India.
Indian drug manufacturers specialize in superior generic drugs. Generic meds are relevant substitute to brand selection, giving similar Viagra pills, but at a lower cost.
One of the drug makers presently generating a heavy impact on European market is Cipla. This India-located enterprise has progressed in final years, working with the world’s largest drug giants to make palpable rapprochement with UK client. Cipla has met Food and Drug Administration models with its tablets, approving the safeness and class of the cures for the Western people.
Though it presents countless medicaments, Cipla has payed the most attention to its alternative to Viagra meds. These pills are generic twins to the widespread impotence drug - Viagra, and have been desired by purchasers of all ages who suffers from ED issues. The Cipla's generics have been declared to be as risk-free and effective as the original meds.
While the safety and performance of Cipla’s medicaments are vital, those points are not the only basises why Cipla is such a significant player in the pharmaceutical market. In contrast to brand pills such as Viagra, Cipla’s generic substitutes are available at a fraction of the price. In fact, major part of Cipla’s cures can be shopped at 5% of the cost. For example, its Viagra alternative medicaments each cost approximately $2 as opposed to $19 in North America. This vital price cutting not only makes these meds more commonly available to the audience, but they also name brand-name pharmacies to cut their prices in order to be competitive.
Viagra price
As more men recieve rx pills and other over the counter medications, World largest drug makers magnify costs tags on their brands. However, in current years, this monopoly on the pharmacy market has been challenged by an not likely country - India.
Drug makers from North America practice in quality generic cures. Generic tablets are far-reaching substitute to brand-name option, giving comparable generic Viagra, but at a insignificant price.
One of the drug manufacturers presently producing a heavy impact on UK market is Cipla. This India-situated business has progressed in final years, working for the world’s largest drug giants to make distinct rapprochement with Canadian buyers. Cipla has met FDA criterions with its pills, attesting the safeness and grade of the products for the European citizens.
Though it supplies a lot of tablets, Cipla has payed the most attention to its Viagra alternative drugs. These cures are generic substitutes to the promoted ED drug - Viagra, and have been searched for by purchasers of all ages who suffers from Erectile Dysfunction. The Cipla's Viagra alternatives have been testified to be as riskless and effective as the original cures.
While the safety and efficacy of Cipla’s medicaments are essential, those aspects are not the only targets why Cipla is such a main manufacturer in the pharmaceutical market. In contrast to branded drugs such as Viagra, Cipla’s generic counterparts are available at a fraction of the price. In fact, most of Cipla’s goods can be shopped at 1/20th of the price. For example, its Viagra alternative drugs each cost approximately $2 as compared to $19 in England. This meaningful cost reduction not only makes these goods more widely available to the community, but they also let brand-name drug manufacturers to lower their prices in order to remain competitive.
How Viagra works
Increase the amount of nitric oxide produced in the penis
Increase the amount of cGMP produced in the penis in response to the nitric oxide
Eliminate the PDE in the penis so that the cGMP builds up instead of getting decomposed by the PDE
Viagra uses method number three -- it eliminates the PDE that is decomposing the cGMP, so cGMP builds up in the penis and has a larger effect on the artery walls. The greater the amount of cGMP the greater the blood flow, and the greater the blood flow the greater the degree of the erection.
The reason that Viagra uses this technique is because of an interesting quirk of PDE.
It turns out that the human body has at least 11 different kinds of PDE that it produces. Only one of those kinds of PDE -- PDE5 -- is found primarily in the penis. Once scientists discovered this fact, the creation of Viagra was relatively simple. All that Pfizer needed to find was a chemical that would selectively block PDE5 and nothing else. With the PDE5 blocked, cGMP could build up in the penis and increase the blood flow there without affecting other parts of the body.
If there were not a unique type of PDE found in the penis, we would not have Viagra today.
So how does Viagra block PDE5?
PDE5 is what is known as an enzyme. An enzyme is a specially folded protein that can speed up a chemical reaction. For example, the article How Cells Work describes the maltase enzyme. Maltase is shaped so that a maltose molecule can fit right in, and when it does, the maltase enzyme breaks the maltose molecule into two glucose molecules.
PDE5 is an enzyme that accepts cGMP and breaks it down. Pfizer needed a chemical that would gum up PDE5 and keep it from doing its job. The chemical that Pfizer discovered is called sildenafil citrate. It fits right into the PDE5 enzyme and disables it.
Viagra contains sildenafil citrate packaged as a pill. When a man takes a Viagra pill, the sildenafil citrate flows throughout his body, but it really only affects the PDE5 enzyme in the penis. The drug stays in the bloodstream for about four hours, and then it is washed out of the blood by the liver and kidneys.